Milk and dairy products in cancer prevention: focus on bovine lactoferrin
Hiroyuki Tsuda*, Kazunori Sekine, Yoshihiko Ushida, Tetsuya Kuhara, Nobuo Takasuka, Masaaki Iigo, Beom Seok Han and Malcolm A. Moore
Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, Japan
Received 12 August 1999; revised 1 December 1999; accepted 1 December 1999. Available online 12 April 2000.
There is also considerable evidence that calcium in milk products protects against colon cancer, while promoting in the prostate through suppression of circulating levels of 1,25-dihydroxyvitamin D3.
Whey protein may also be beneficial, as shown by both animal and human studies, and experimental data have demonstrated that the major component bovine lactoferrin (bLF), inhibits colon carcinogenesis in the post-initiation stage in male F344 rats treated with azoxymethane (AOM) without any overt toxicity.
The incidence of adenocarcinomas in the groups receiving 2% and 0.2% bLF were thus 15% and 25%, respectively, in contrast to the 57.5% control value (P<0.01 and P<0.05, respectively). Results in other animal models have provided further indications that bLF might find application as a natural ingredient of milk with potential for chemoprevention of colon and other cancers.